Theme01: Autoimmune Diseases

We need eager partners for collaborations to develop promising new drugs for the treatment of autoimmune diseases. These collaborations will lead to our company’s goal of “Creating for Tomorrow” for the treatment of autoimmune diseases.

Pharmaceuticals Research Center
Laboratory for Pharmacology

Creating for Tomorrow


“ Autoimmune Diseases ”

Recruitment theme 

Autoimmune disease

1-1 Novel drug target molecules, candidates, and therapeutic concepts in autoimmune diseases

Target disease 1: Systemic lupus erythematosus (SLE)

Research interests:

  • Treatment concept for the improvement of renal function

Untargeted research:

  • Research that targets only cutaneous lupus erythematosus (CLE)

Other conditions:

  • In vitro experimental results demonstrating the mechanism of action and expectations to improve renal function must have already been obtained.
  • Difference points from drugs launched and under development are required.

Target disease 2. Primary Sjögren’s syndrome (pSS)

Research interests:

  • Research on drug targets to inhibit T cell (cytotoxic or tissue-resident memory T cells) and/or B cell function
  • Treatment concepts for interstitial lung disease (ILD) associated with pSS (pSS-ILD)
  • Treatment concept for the improvement of renal function

Other conditions:

  • In vitro experimental results demonstrating the mechanism of action must have already been obtained.
  • Difference points from drugs under development are desirable.

Target disease 3. Systemic sclerosis (SSc)

Research interests:

  • Research on drug targets to suppress immune systems and prevent fibrosis
  • Research on drug targets to inhibit cytotoxic T cell function
  • Treatment concepts for SSc-ILD

Other conditions:

  • In vitro experimental results demonstrating the mechanism of action must have already been obtained.
  • Difference points from drugs launched and under development are desirable.

Target disease 4. Polymyositis/dermatomyositis (PM/DM)

Research interests:

  • Research on drug targets for immunosuppression
  • Research on drug targets to inhibit cytotoxic T cell function
  • Treatment concepts for PM/DM-ILD

Other conditions:

  • In vitro experimental results demonstrating the mechanism of action must have already been obtained.
  • Difference points from drugs under development are desirable.

Target disease 5. Other autoimmune diseases

  • Research that already has a drug candidate (including the pre-optimization stage)
  • Research that targets only rheumatoid arthritis, inflammatory bowel disease, psoriasis, multiple sclerosis, myasthenia gravis, and type 1 diabetes is not eligible for recruitment.
1-2 Next-generation technologies for antigen-specific immune tolerance
  • Research on autoimmune diseases
  • Research on the induction of antigen-specific Treg and/or T cell anergy in vivo
  • Research on the inhibition and/or removal of antigen-specific dendritic cells in vivo

Other conditions:

  • In vivo experimental results demonstrating the content of the research must have already been obtained. Therapeutic effect is desirable.
  • Clarification of the mechanism of action at the molecular or cellular level is desirable.
  • Unique difference points from technologies under development, such as an immediate response and immune tolerance to protein antigens, but not specific peptides, are required.

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